Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer

PA Dugué; C Yu; AM Hodge; EM Wong; JHE Joo; CH Jung; D Schmidt; E Makalic; DD Buchanan; G Severi; DR English; JL Hopper; RL Milne; GG Giles; MC Southey

Journal article

Methylation scores for smoking, alcohol consumption and body mass index and risk of seven types of cancer

PA Dugué, C Yu, AM Hodge, EM Wong, JHE Joo, CH Jung, D Schmidt, E Makalic, DD Buchanan, G Severi, DR English, JL Hopper, RL Milne, GG Giles, MC Southey

International Journal of Cancer | WILEY | Published : 2023

DOI: 10.1002/ijc.34513

Abstract

Methylation marks of exposure to health risk factors may be useful markers of cancer risk as they might better capture current and past exposures than questionnaires, and reflect different individual responses to exposure. We used data from seven case-control studies nested within the Melbourne Collaborative Cohort Study of blood DNA methylation and risk of colorectal, gastric, kidney, lung, prostate and urothelial cancer, and B-cell lymphoma (N cases = 3123). Methylation scores (MS) for smoking, body mass index (BMI), and alcohol consumption were calculated based on published data as weighted averages of methylation values. Rate ratios (RR) and 95% confidence intervals for association with ..

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University of Melbourne Researchers

Allison Hodge Author

Eric Joo Author

Chol-Hee Jung Author

Daniel Schmidt Author Melbourne School of Population and Global Health

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Grants

Awarded by VicHealth

Funding Acknowledgements

Australian National Health and Medical Research Council, Grant/Award Numbers: 1164455, 209057, 251553, 504711, 1011618, 1026892, 1027505, 1050198, 1043616, 1074383, 1061177